I consent to the use of cookies on this page for analyses, personalised content and advertising.

    Publication search

    Our research and development teams operate at a global level and generate synergies from our collective expertise and by drawing on related disciplines. We are also constantly exchanging information at an international level with independent technical institutions, key opinion leaders and multipliers in order to be able to ensure cooperation and knowledge management of the highest order. As part of this process, we also conduct extensive research, the results of which we continually present in workshops, at conferences and symposiums - either in documentation or talks given by our cooperation partners - and also publish in renowned scientific journals. This database contains a large number of these evidence-based scientific articles, most of which have been evaluated by independent assessors:

    1. Poster

      A review of monofilament fibre technology in the management of a variety of dermatological conditions

      Poster presented at EWMA 2018 09.05.2018 Krakow, Poland

      Aim:

      To review the evidence supporting the use of Monofilament fibre debridement technology (MFDT) in dermatological conditions.

       

      Method:

      MFDT has been successfully used for 7 years in the debridement and management of chronic wounds¹ and hyperkeratosis². In recent years clinicians have been utilizing the MFT in specific dermatological skin conditions.

       

      Results / Discussion:

      MFDT has been shown in case studies and case series to be a useful emerging treatment, especially when self-care is a priority, in the management of dermatological conditions resulting in:

       

       Varicose eczema

       Epidermolysis bullosa

       Chronic wounds in dermatological patients

       Dry, scaly and flaky skin conditions

       Hyperkeratosis associated with venous disease

       Secondary skin changes associated with chronic oedema and lymphoedema

       Actinic keratosis

       Prior to photodynamic therapy

       Acne vulgaris

       

      The 18 million special monofilament fibres which have angled tips to reach uneven areas of the skin or wound bed are able to remove unwanted tissue, materials and skin, allowing other concurrent treatment to reach their target area without the barriers imposed by for e.g. devitilised tissue, dry, scaly and flaky skin and other debris and materials. This technology has received positive NICE guidance¹⁷ for use in acute and chronic wounds. MFDT is very soft, comfortable and gentle on patients. It is safe and easy to use and can also be used by patients for self-care.

       

      Conclusion:

      A review of the supporting evidence clearly supports the continued research and interest in MFDT related to dermatological conditions.

    2. Poster

      First experiences in use of a monofilament fibre pad* in treatment of patients suffering from retentive and cystic manifestation of acne*

      Poster presented at EWMA 2018 09.05.2018 Krakow, Poland

      Introduction:

      Acne vulgaris is a common problem in youth and early adolescence and it is characterized by areas of skin with increased oil-sebum secretion (seborrhea) and formation of comedones, papules, pustules, as well as nodules [1,2]. Frequently, scarring is the result of the inflammatory processes within the dermis. Acne vulgaris traces back to an enlargement of sebaceous glands and an enhancement in sebum production linked to an increased production of sexual hormones (e.g. androgens). Acne then develops when sebaceous glands becoming clogged with sebum (microcomedo). These microcomedos are able to enlarge to form an open comedo (so called “blackhead” due to the fact that oxidation of sebaceous material at the porus is changing colour) or closed comedo (also called “whitehead” and often associated to cystic sebum retention). Typically, under such conditions naturally occurring bacteria can cause inflammation, leading to inflammatory lesions (papules, infected pustules, or nodules) in the dermis around the comedone [3]. For management of acne, any different treatment recommendations exist, including different pharmacologic and non-pharmacologic opportunities to remove the sebaceous clogging [3]. They are aimed to normalize shedding and sebum production to prevent blockage of pores. Additionally, reduction of microbial bioburden, exertion of antiinflammatory effects, and manipulation of hormone production are in therapeutic focus. Additionally, a strict regime for skin lavation is recommendable to remove surplus sebum and prevent clogging. Thus, however, can be supported by effective mechanical removal of excessive sebum formation. This could be amended by using a monofilament fibre debridement pad, which has been designed to provide fast, effective mechanical removal of proteinaceous crusts that is pain- and trauma free. First in-vitro testing [4] was able to demonstrate efficacy in cleaning by using the debridement model with artificial sebum.

       

      Methods:

      During a time period of four months, a semi-systematic case series was performed in young people suffering from retentive manifestation of acne vulgaris to collect practical aspects of the use of the monofilament fibre pad in combination with typical dosage forms of polyhexanide (PHMB) and Sodium-hypochlorite based solutions (medical devices) in order to achieve first practical experiences in combined use. This small case series was focused on comfort aspects, acceptance and clinical benefit in use. Application has taken place periodically thereafter as necessary daily up to twice weekly.

       

      Results / Discussion:

      Results achieved (n=7): “Pad handling” excellent in six and acceptable in one case. After single use, reduction of sebum retention was excellent in three and acceptable in four cases. Results have been improved to six “excellent” and one

      “acceptable” after repeated use. “Treatment comfort” and “compatibility” achieved excellent in all cases. The overall acceptance and user satisfaction were encouragingly positive. Application was “very comfortable” and “easy in use” for all cases. Cleaning efficacy was very satisfactory and seemed to be superior compared to cosmetic pads. Combination with different cleaning solutions was fully compatible.

       

      Conclusion:

      First clinical experiences in use of the monofilament fibre pads were exceedingly satisfactory. Removal of sebum retention was efficient and combination with different cleaning solutions did not show any signs of incompatibility. Hence, a systematic approach to collect clinical data would be very much appreciated.

      Products Debrisoft Pad
      Further versions
    3. Poster

      The real value of mechanical debridement in complex wounds - a clinical study

      Poster presented at EWMA 2018 09.05.2018 Krakow, Poland

      Aim:

      The study compared clinical efficacy and cost of autolitic, enzymatic and mechanical debridement using a monofillament pad* and a pad with a handle.

       

      Method:

      A monofilament debrider was proposed for its efficacy, safety, tolerability and ease of use. Eighty community patients with complex wounds containing sloughy tissue were allocated to the treatment groups at random, after they consented. They were followed for 15 days. At baseline medical history, wound characteristics and privious treatment was recorded. During visits wound condition, patient reported pain during debridement, time required for the procedure and product handling, were scored. Costs calculation took into account clinical efficacy, time to debridement, number of home visits, nursing costs, costs

      per product used.

       

      Results / Discussion:

      Debridement was effective and comfortable using all evaluated methods (on a 5-point Likert scale, the 2 monofilament products scored a mean of 4,9 and 4,8, enzymatic sored a mean of 4,6 and autolytic debridement a mean of 3,6). The total costs for debridement using the monofilament pad* and product with handle was Euro 58,67 and Euro 72,47 respectively. For enzymatic debridement the total costs were Euro 213,35 and for autolytic debridement Euro 98,67. Cost was significantly lower in the monofilament group due to a reduction in debridement time, number of visits and nursing time.

       

      Conclusion:

      The addition of the monofilament products to our debridement portfolio use for wound management in the community represents an added value in the treatment available for patients with complex wounds with appropriate use of tight resources.

      Products Debrisoft Pad
    4. Poster

      A super absorbent dressing* for management of patients with moderate-to-highly exuding wounds - a clinical study

      Poster presented at EWMA 2018 09.05.2018 Krakow, Poland

      Aim:

      A polyacrylate containing super absorbent dressing* can be used for patients with moderate-to-high exuding wounds. The study evaluated the performance of the superabsorbent dressing* in daily clinical practice.

       

      Method:

      German physicians from different specialisms participated: 23 general medicine, 13 surgery, 14 internal medicine and 3 other departments. Both the dressing and questionnaire were supplied by the sponsor. After dressing use the physicians scored on handling properties, absorbent capacity, user satisfaction and patient comfort. The super absorbent dressing* was used for at least 3 dressing changes in 171 patients (86 (50.3%) men, 78 (45.6%) women, 7 (4.1%) not scored).

       

      Results / Discussion:

      The centers used their current protocol. The patients had pressure ulcers (8 (4.7%), venous leg ulcers (113 (66%), diabetic foot ulcers (8 (4.7%), post-surgery (14 (8.2) and infected wounds (8 (4.7%). Dressing application was rated easy by 168 (95%) of the clinicians and the dressing demonstrated a good absorbent capacity as noted by 167 (98%) of the respondents. The dressing was rated easy to remove (168 (98.3%) and did not soil clothing according to 165 (97%) of the respondents. N=157 (94%) patients reported to be satisfied with the performance of the dressing as well as 166 (99%) of the physicians, who additionally reported (156 (94.6%) the dressing to be safe and reliable for the task at hand.

       

      Conclusion:

      The study design allowed for collecting data on the dressing in daily clinical practice. The evaluated dressing* was easy to use, comfortable and reliable for patients with moderate-to-high exuding wounds.

      Products Vliwasorb Pro
    5. Poster

      Guidelines, assessment, appropriate referrals and treatment can improve patient outcome

      Poster presented at EWMA 2018 09.05.2018 Krakow, Poland
    6. Poster

      Assessment of The Cleansing Capacity of a Monofilament Debrider Compared to Conventional Cosmetic Pads in an Acne Sebum Model

      Poster presented at EWMA 2018 09.05.2018

      Aim:

      Acne is a long-term, multiform skin disease that is characterized by increased sebum production (seborrhea) and comedo formation (blackheads or whiteheads). However, over time, inflammatory papules, pustules, and nodules may develop. For acne treatment, several options are available with the aim to normalize skin cell shedding and sebum production in the pore to prevent blockage and kill bacteria (such as P. acnes) to reduce inflammation. Hence, frequent cleansing of the skin is necessary without adding to the skin irritation. The recently introduced monofilament debrider may present a beneficial option, removing the protein-rich crusts, effectively, fast, and pain-free.

       

      Method:

      The sebum model consists of glass plates coated with an oil-red-stained layer of artificial sebum. The monofilament debrider* and conventional cosmetic pads**,***,**** were used to clean the glass plates under standardized conditions (p=0.067N/cm2, v=1.6cm/s). Images were obtained before and after treatment and processed using ImageJ 1.45m.

       

      Results / Discussion:

      The monofilament debrider* exhibited a significantly higher cleansingefficacy compared to the cosmetic pads in vitro. While the monofilament debrider* was able to remove the artificial sebum almost completely (98.9% cleansed area), significantly lower efficiencies were noted for the conventional cosmetic pad**(46.9%), the conventional cosmetic pad***(76.2%), and the conventional cosmetic pad**** (54.7%).

       

      Conclusion:

      Treatment of acne vulgaris requires an efficient skin cleansing to remove surplus sebum and prevent pore blockage. However, added irritation of the skin should be avoided. Using a model with artificial sebum, it could be shown that the cleansing capacity of the new monofilament debrider is significantly higher compared to commercially available cosmetic pads.

      Products Debrisoft Pad
    7. Poster

      Wound related pain during debridement using monofilament debridement pads

      Poster presented at EWMA 2018 09.05.2018

      Aim:

      Debridement is key to management of both slough and biofilm, and a number of methods are available to achieve this including surgical and mechanical debridement. Recent developments have led to new products indicated for debridement of wounds, including a unique sterile pad consisting of monofilament fibres. The purpose of this project was to examine wound related pain during mechanical debridement using monofilament debridement pad (WDP).

       

      Method:

      This is a case series of 10 patients with acute or chronic wounds that had slough required debridement. All wounds were debridement weekly for four weeks. Pain at baseline and during the debridement procedure (procedural pain) was evaluated using a verbal analogue scale (VAS) on which 0 was no pain and 10 was the worst pain imaginable.

       

      Results / Discussion:

      The wounds treated (number) were surgical wounds (3); pressure injury (3); venous leg ulcer (2); diabetic foot ulcer (1); trauma wound (1). The mean surface area covered by slough in the 10 wounds at week 0 was 79%. In every case the surface area of the wound covered by slough at week 0 reduced by week 4 to a mean of 8%. The average pain score at baseline was 6 in comparison to the mean pain of 7 during the debridement procedure using monofilament pads.

       

      Conclusion:

      WDP provides an effective solution to the goal of removing loose slough, deeply cleaning wounds and removing exudate. WDP does not induce high levels of procedural pain and any such pain subsided once debridement was complete.

      Products Debrisoft Pad
    8. Poster

      PROVIDING COMPRESSION OPTIONS:THE KEY TO BETTER COMPLIANCE AND CONCORDANCE FOR PATIENTS LIVING WITH CHRONIC EDEMA

      Poster presented at EWMA 2018 09.05.2018 Krakow, Poland

      Aim:

      Compression remains the gold standard for long-term management of chronic edema. Reviews have shown that the benefits of compression diminish according to levels of non-adherence. Reasons commonly stated for nonadherence to compression include inconvenience, heat, cost, and pain. We hypothesize that offering compression options will have positive impact on patients’ compliance and concordance to compression regimens.

       

      Method:

      Observational study performed at 2 different edema management clinics. Ten patients presenting with lower extremity swelling and history of non-compliance with previous compression regiments were observed. Objective data measured included limb volume, range of motion (ROM), functional activity status using the Timed Up and Go(TUG), and assessment of quality of life (QOL) using the Lymphoedema QOL Tool (LYMQOL-LEG). Measurements were taken at four different intervals over a minimum of 3 months. Compression options were individualized to patient's physical presentation and lifestyle for long term management of their edema.

       

      Results / Discussion:

      Compression therapy had a positive impact on all outcomes measured during the intensive phase of therapy. Follow-up outside the intensive phase of therapy demonstrated further volume loss in 6/10 subjects; Volume remained constant 3/10, increased slightly 1/10. LYMQOL scores and functional performance level maintained stable during the follow-up period.

       

      Conclusion:

      Offering multiple compression options including custom and ready-to-wear flat knit stockings*, an adjustable wrap ** and nighttime compression options*** had a positive impact on patients’ adherence to compression regimens during the study period compared to single compression modalities offered previously. Individualizing the compression regimen to each patient’s lifestyle improved their adherence to chronic edema management.

      Products Rosidal TCS
    9. Poster

      A NEW PHMB-CONTAINING PU FOAM* EXERTS ANTIBACTERIAL EFFECTS ON PSEUDOMONAS AERUGINOSA AND A STAPHYLOCOCCUS AUREUS BIOFILM

      Poster presented at EWMA 2018 09.05.2018 Krakow, Poland

      Aim:

      Chronic wounds are often colonized by different microorganisms, the most prominent being Staphylococcus aureus and Pseudomonas aeruginosa. PHMB-containing dressings have been shown to effectively inhibit bacterial progeny. However, bacteria do not act alone and the concept of biofilm formation and presence is now widely accepted. Therefore, current research targets antibiofilm strategies to restore an optimal wound-healing environment. A combined treatment approach involving debridement and the addition of antibacterial agents may then provide the highest success rates. Here, the efficacy of the new PHMB-containing PU foam* against a Staphylococcus aureus biofilm was evaluated in vitro. Moreover, antibacterial activity was evaluated in a direct contact method against Staphylococcus aureus and Pseusomonas aeruginosa.

       

      Method:

      Antibacterial activity against S. aureus and P.aeruginosa was tested according to JISL1902:2002. S.aureus biofilm was cultivated on glass plates, covered with dressings, and incubated for 24h at 37°C. Biomass was evaluated directly after dressing removal and following 48h regrowth period using the alamar blue assay.

       

      Results / Discussion:

      The new PHMB-containing PU foam* displayed complete inhibition of S.aureus and P.aeruginosa in the direct contact test, rated as strong antibacterial activity according to JISL1902:2002 (log-reduction>3). Treatment of S.aureus biofilm with the new PHMBcontaining PU foam* efficiently reduced biomass and significantly less viable bacteria were observed.

       

      Conclusion:

      It was found that the new PHMB-containing PU foam* exhibits a strong antibacterial activity against prominent microorganisms in chronic wounds. Moreover, it could be shown to reduce biofilm. Hence, it can be expected to exert beneficial effects in stagnating wounds and promote healing.

      Further versions
    10. Poster

      NON-ANTIBIOTIC ANTIMICROBIAL TECHNOLOGY WOUND DRESSINGS EXERTING AN ANTIBACTERIAL EFFECT ON PSEUDOMONAS AERUGINOSA AND A STAPHYLOCOCCUS AUREUS BIOFILM IN VITRO

      Poster presented at EWMA 2018 09.05.2018 Krakow, Poland

      Aim:

      Increased bacterial loads on the wound surface amplify and/or perpetuate a proinflammatory environment. It was suggested that lower probability of healing is seen when ≥4 pathogens are present. Biofilm formation further lowers the probability of healing. Hence, it was postulated that it is necessary to create conditions that are unfavourable to microorganisms and favourable for host repair mechanisms. Dressings featuring active antimicrobial agents or a passive antimicrobial mechanism may help in the treatment of chronic wounds.

       

      Method:

      DACC-coated1, SAP2, activated-charcoal/Ag3, and biocellulose/PHMB4 dressings were investigated. Antibacterial activity against P.aeruginosa was tested according to JISL1902:2002. S.aureus biofilm was cultivated on glass plates, covered with dressings, and incubated for 24h at 37°C. Biomass was evaluated directly after dressing removal and following 48h regrowth period using the alamar blue assay.

       

      Results / Discussion:

      All dressings displayed complete inhibition of P.aeruginosa, rated as strong antibacterial activity according to JISL1902:2002 (log-reduction>3). Treatment of S.aureus biofilm with the dressings efficiently reduced biomass and significantly less viable bacteria were observed. However, only the biocellulose/PHMB4 dressing exhibited a remanescent effect and was able to inhibit biofilm regrowth over 48h.

       

      Conclusion:

      Antimicrobial dressings can decrease multiplication of bacteria by passive mechanisms based on securely binding microbes in or to the dressing as observed for DACC-coated1 or SAP2 dressing. Dressings actively releasing agents like Ag+ or PHMB have additional effects reaching bacteria beyond direct dressing contact. Here, PHMB was found to be superior to Ag+ demonstrating a remanescent effect and preventing biofilm regrowth.

      Further versions
      Further languages