Ricerca della pubblicazione

I nostri team di ricerca e sviluppo sono distribuiti in tutto il mondo, generando sinergie grazie alle nostre competenze specializzate e discipline correlate. Partecipiamo a uno scambio internazionale con istituzioni specializzate indipendenti, opinion leader e moltiplicatori chiave, al fine di garantire la cooperazione e la gestione delle conoscenze ai massimi livelli. Come parte di questo impegno, conduciamo ricerche approfondite che vengono continuamente presentate ai congressi sotto forma di poster o conferenze dai nostri partner di cooperazione, nonché ai simposi e workshop, e pubblicati su riviste scientifiche rinomate. Le pubblicazioni specialistiche basate sulle evidenze, per lo più valutate da revisori indipendenti, sono disponibili in questo database:

  1. Poster

    The use of night time garments for chronic oedema management impacts patients’ quality of life and oedema management

    Poster presented at ALA Virtual Conference 2020 28.05.2020 Hobart, Australia

    Aim

    Successful management of chronic edema requires a commitment to compression bandaging, garments and/or use of alternative bandage wraps.1-2 Some patients require continuous compression day and night.1,3 The aim of this investigation was to assess the impact on volume control and patients’ quality of life (QOL) with the addition of a nighttime garment to their compression regiment.

     

    Methodology

    This observational study details four patients (n=4) medical history, subjective reports and objective measurements of limb volume and self-reported QOL before, during and after the addition of a nighttime garment to their compression regiment. Circumferential measurements were taken to track limb volume and The Lymphedema Quality of Life (LYM-QOL)4 questionnaire was used to capture patient’s self-reported improvement in quality of life. The assessment period was over a minimum of 6 weeks. Measurements were taken at three different intervals.

     

    Results

    It was observed that all subjects had an improvement in their self-reported quality of life (via LYM-QOL). Limb volume was stable in two out of four patients. Two out of four demonstrated further volume loss with the addition of nighttime product.

     

    Conclusion

    The addition of a nighttime compression device demonstrated positive change in self-reported QOL as well as better overall edema management. Patients who previously had struggled with long term edema management demonstrated improved edema control. Additional investigation is warranted to study impact of inclusion of a night time garment as part of the standard of care for those patients living with chronic edema.

    Further versions
  2. Poster

    Providing Compression Options: The Key to Better Compliance and Concordance

    Poster presented at ALA Virtual Conference 2020 28.05.2020 Hobart, Australia

    Aim:

    Compression remains the gold standard for long-term management of chronic edema. Reviews have shown that the benefits of compression diminish according to levels of non-adherence. Reasons commonly stated for nonadherence to compression include inconvenience, heat, cost, and pain. We hypothesize that offering compression options will have positive impact on patients’ compliance and concordance to compression regimens.

     

    Method:

    Observational study performed at 2 different edema management clinics. Ten patients presenting with lower extremity swelling and history of non-compliance with previous compression regiments were observed. Objective data measured included limb volume, range of motion (ROM), functional activity status using the Timed Up and Go(TUG), and assessment of quality of life (QOL) using the Lymphoedema QOL Tool (LYMQOL-LEG). Measurements were taken at four different intervals over a minimum of 3 months. Compression options were individualized to patient's physical presentation and lifestyle for long term management of their edema.

     

    Results / Discussion:

    Compression therapy had a positive impact on all outcomes measured during the intensive phase of therapy. Follow-up outside the intensive phase of therapy demonstrated further volume loss in 6/10 subjects; Volume remained constant 3/10, increased slightly 1/10. LYMQOL scores and functional performance level maintained stable during the follow-up period.

     

    Conclusion:

    Offering multiple compression options including custom and ready-to-wear flat knit stockings*, an adjustable wrap ** and nighttime compression options*** had a positive impact on patients’ adherence to compression regimens during the study period compared to single compression modalities offered previously. Individualizing the compression regimen to each patient’s lifestyle improved their adherence to chronic edema management.

    Products Rosidal TCS
    Further versions
  3. Poster

    Tissue fibrosis is improved with addition of textured compression garment to patients’ chronic oedema management program

    Poster presented at ALA Virtual Conference 2020 28.05.2020 Hobart, Australia

    Aim

    Chronic edema is associated with significant trophic changes including not only increased volume but also trophic changes.1-3 Compression has been shown to have a positive impact on trophic changes including reduced tissue fibrosis.1-4 It has been observed that textured compression, utilizing chipped foam or channeled foam, has a significant improvement on tissue fibrosis.5 Aim of this study was to objectively measure the change in tissue fibrosis following the use of a textured compression product.

     

    Methodology

    Observational study tracking outcomes of four patients (n=4) utilizing a textured compression garment at night. Garments were chosen as best fit for patient by therapist and were not the same across the subjects. Measurements included: volume of the limb, tissue density, and subject self-reported quality of life. Measurements were taken at three different intervals over a two month period. Tissue fibrosis was taken as a tissue density measurement using a tissue tonometer.6-8 The Lymphedema Quality of Life (LYM-QOL) questionnaire was used to capture patient’s self-reported improvement in quality of life. 9

     

    Results

    In all subjects, both volume and tissue fibrosis were reduced. Two out of four subjects were recorded with at least a 5% reduction in volume and three out of four subjects recorded a 5% or greater tissue density improvement.

     

    Conclusion

    This study was limited by several variables. Such as, garments were chosen as best fit for patient by therapist and were not from same manufacturer or style across the subjects. Generally, these patients had previous lymphedema treatment and had nearly stable volumes, but significant fibrosis limiting their concordance with regimen. There are other tools, such as, an indurometer, which may allow more accurate measurement of fibrosis.

    The use of textured compression garments as part of a night time regimen reduced tissue fibrosis for patients with chronic edema. Patients in this study demonstrated improved concordance as evidenced by stable volume and reports of compliance, with improved quality of life in all subjects. Additional study is warranted to assess further impact on overall compliance and concordance in garment regimen with reduction in fibrosis of the limb.

    Further versions
  4. Poster

    Establishment of a moist environment by a new foam dressing* beneficial for wound healing in vitro

    Poster presented at CICA 2020 26.01.2020 Paris, France

    Introduction

    Modern wound dressings are expected to maintain a humid wound milieu, which is thought to aid cell proliferation and migration resulting in faster and better wound healing. Foam dressings are thought to aid in the establishment of a beneficial moist wound environment as they exhibit excellent fluid management capacity by absorbing as well as donating fluid. Therefore, a scratch wound healing model using human fibroblasts and keratinocytes was developed depending on the donation of fluid by the applied dressings. The effect on cell proliferation and migration necessary for wound healing and epithelization was investigated for the new foam dressing (NFD)* and compared to cotton gauze as standard of care dressing (SOCD)**.

     

    Material & Methods

    Human dermal fibroblasts (DF) and human epidermal keratinocytes (HaCaT) were seeded into 6-well-plates and cultivated for 48h until confluence before scratching. Cell scratches cultivated in medium served as positive controls for optimal wound healing (figure 1). Samples of NFD (*Suprasorb® P sensitive, Lohmann&Rauscher) and SOCD (**cotton gauze, Fuhrmann) were cut aseptically (d = 3.5 cm), soaked in medium and applied directly on the cell scratches without further addition of medium supply. Cells were stained with hematoxylin/eosin after 1, 6, 24, and 48 hours. Scratches were photographed using a digital microscope (Keyence) and the scratch area was evaluated using the Image J program.

     

    Results

    Scratches covered with SOCD cotton gauze exhibited no tendency for healing (figures 2 and 3), which could be attributed to a distinct parching of the cells under the conditions of the scratch wound assay+. Accordingly, cells featured a roundish phenotype and cell confluence was partly lost with the scratches remaining open at the end of the experiment. In contrast, NFD supported the scratch healing in vitro by promoting keratinocyte (figure 2) and fibroblast (figure 3) proliferation and migration through establishing a moist wound environment. A slight tendency of the cells to adhere to the foam dressing, which provides a 3D matrix for the cells, could be observed featuring a possible explanation why scratch healing under the dressing samples was slower compared to the medium control.

     

    Conclusion

    A scratch wound healing model using human fibroblasts and keratinocytes depending on the donation of fluid by the applied dressings could be successfully developed. It can be used to assess the capacity of wound dressings for establishing a moist wound environment that is thought beneficial for healing. Here, it could be shown that the NFD is able to promote wound healing in vitro by effectively creating humid conditions favouring wound closure while the SOCD was not able to maintain the moist environment resulting in nonhealing cell scratch wounds in vitro.

    Further languages
  5. Journal article

    In-vivo-Druckmessungen zum Vergleich medizinischer adaptiver Kompressionssysteme mit maßangefertigter Flachstrick-Kompressionsversorgung

    Phlebologie 2020

    Hintergrund

    Die in der Erhaltungsphase der komplexen physikalischen Entstauungstherapie notwendige Kompressionstherapie kann anstelle von Flachstrick-Kompressionsstrümpfen (FS) auch mit vom Patienten selbst anzulegenden Bandagen erfolgen, den sogenannten medizinischen adaptiven Kompressionssystemen (MAK).

     

    Methoden

    MAK und FS wurden mittels In-vivo-Druckmessungen unter der von Probanden selbst angelegten Kompression direkt verglichen. Dazu wurden Drücke über Picopress®-Messgeräte und Sensoren (Microlab Elettronica, Italien) an n = 30 Patienten mit beidseitigen, symmetrischen, lymphostatischen Ödemen der Unterschenkel erfasst. FS und MAK wurden seitenrandomisiert zugewiesen. Nach Standardeinweisung und initialen Druckmessungen beider Systeme wurden MAK im Zeitverlauf von 2 und 4 h Tragedauer erneut gemessen. Static-Stiffness-Index (SSI) sowie Druckgradienten der Messhöhen B1-C wurden berechnet.

     

    Ergebnisse

    MAK zeigen Ruhedruckwerte und SSI im therapeutischen Bereich, die signifikant höher ausfallen als bei FS (p < 0,01 bzw. p < 0,001). MAK erreichen signifikant höhere maximale Arbeitsdrücke (p < 0,001). Die Ruhedruckwerte von MAK zeigen nach 2 und 4 h, ohne Nachjustieren, keinen relevanten Druckabfall. Die mittleren Druckgradienten, bezogen auf die Messhöhen B1-C, unterscheiden sich nicht signifikant zwischen den Methoden.

     

    Diskussion

    Die mit MAK erreichten Druckparameter untermauern deren therapeutische Effektivität. Die Anwendung von MAK ist auch ohne Nachjustieren druckstabil. Die Anwendung (Selbstanlage) kann als therapeutisch wirksam eingestuft werden. Eine gute Einweisung der Patienten ist jedoch bedeutsam.

  6. Journal article

    Adjustable Compression Wraps are Non-Inferior to Custom-Made Flat Knit Compression Stockings in the Maintenance Phase of Complex Decongestive Therapy

    Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin 2020

    Background

    Evidence supports the use of adjustable compression wraps (ACW) in the intensive phase of complex decongestive therapy (CDT), whereas evidence of its use in the maintenance phase of oedema therapy is sparse.

     

    Methods

    Randomised controlled non-inferiority trial in the maintenance phase of oedema therapy (CDT phase II) of symmetric lymphostatic oedema of the lower leg. Oedema therapy was performed with ACW and custom-made flat knit compression stockings (FCS) as a reference therapy in parallel over 3 days in n = 30 subjects. The primary outcome was lower leg volume as measured with perometer. Safety of ACW self-application and the patient perspective were secondary outcomes.

     

    Results

    ACW is non-inferior to custom-made FCS in CDT phase II of lymphostatic lower leg oedema. The differences of volume effects lie within the apriori defined equivalence interval of ± 50 ml (p = 0.163; 95 %-CI [ − 38.2; + 6.8]). Self-administration of ACW has shown no relevant side effects. ACW are easier to put on and off, while wearing comfort is comparable.

     

    Conclusions

    ACW are an alternative therapy option in the maintenance phase of CDT. Self-application seems to be safe, subject to diligent instruction of patients. Patients with difficulties putting on and off compression stockings could benefit from the use of ACW. Patients with pronounced limb volume may need to wear shoes with bigger sizes when wearing ACW. Further research with a longer observation time is to follow.

    Further languages
  7. Journal article

    A small scale quality improvement study trialling the use of a monofilament-fibre (Debrisoft®) debridement lolly on chronic ulcers

    Wounds UK 2020 16(1)

    Objective:

    A small-scale quality improvement study to determine the clinical effectiveness and patient satisfaction of the long-handled monofilament fibre (Debrisoft®) debriding lolly on foot ulcers that were considered to be slow healing in nature.

     

    Methods:

    This was a non-comparative, small-scale quality improvement study conducted on ulcers with slough (non-fibrous) at the ulcer base. The longhandled monofilament fibre (Debrisoft®) debriding lolly was used to treat seven patients during ulcer management, following the Trust's guidance for podiatric ulcer treatment.

     

    Results:

    Improvement was noted to the majority of ulcers within the second to third week and visible changes were evident, particularly in healing times and slough reduction. Both user and patient satisfaction were high.

     

    Conclusion:

    The long-handled monofilament fibre (Debrisoft®) debriding lolly provides an easy-to-use method of debriding foot ulcers. It allows easy access to difficult areas and enables the healing mechanism to commence. Patients verbally reported positive satisfaction when the long-handled monofilament fibre (Debrisoft®) debriding lolly was used.

    Products Debrisoft Lolly
  8. Poster

    Surgical treatment of extended Keloid scar with dermal substitute, negative pressure wound therapy and partial thickness skin graft: A case study

    Poster presented at Wounds UK 2019 04.11.2019 Harrogate, UK

    Introduction

    Keloids (keloid disorder and keloidal scars) develop at the site of a previous injury as a thick fibrous lesion as a result of aberrant wound healing that is characterized by ongoing, yet localized inflammation. Keloids result as the overgrowth of granulation tissue (collagen type 3) at the site of healed skin, which is then slowly replaced by collagen type 1. Keloids are benign lesions that usually are firm, rubbery and shiny. They can vary from pink to the patient’s skin color and be accompanied by severe itchiness and pain. Keloids can be distinguished from hypertrophic scars by their horizontal growth surpassing the original wound margins and their failure to resolve over time. [1,2] Keloid development rests on genetic and environmental factors, they tend to occur more frequently in female patients aged 10-30. [3] A positive correlation to skin pigmentation has been observed, meaning a higher prevalence in individuals with coloured skin. [2] Keloids are often associated – not only with cosmetic issues – but with functional impairment due to its contractional behavior. [4] Surgical excision of keloids alone has consistently shown poor results, as it generally results in high recurrence-rates of 40 to 100 percent. [3] Often therapy of keloid is multi-modal, combining local pressure, silicone sheeting, intralesional injection of cortisone and/or local radiotherapy. [4]

     

    Method

    After the excision of the scar lesion, the full thickness skin defect was reconstructed in stages. To reconstruct a sufficient dermal layer, we locally applied a dermal substitute, initially covered with a meshed silicone sheet (bilayer dermal matrix). To adequately steady the matrix and avoid shear stress, we used the technique of NPWT in general and a very easily manageable sleeve-like dressing in particular. The dressing was changed approximately every 5-6 days and the arm was further immobilized with a removable splint. Once the three-dimensional dermal matrix showed a sufficient ingrowth of granulation tissue, the silicone layer was detached and a meshed partial thickness skin graft harvested with a dermatome from the ipsilateral thigh was applied. It was again temporarily sealed with a NPWT-device, in order to adequately steady the graft, accelerate its attachment to the dermal matrix and eliminate exudate. [5]

     

    Results

    After complete healing of the graft, the patient is pain-free and no longer limited in her movements. At 1.5 years of follow-up there is no sign of recurrence for keloid.

     

    Discussion

    The excision of large surface keloids overpassing joints and the use of a dermal matrix associated with skin grafts is a useful technique for restoring full thickness skin defects, particularly on the extremities. Yet, adequate immobilization to avoid local shear stress is often difficult and cumbersome. NPWT is known to perfectly mold the grafts to the wound. Yet, its application using gauzes or cut out foams and several pieces of transparent and self-adhering films is often difficult and time-consuming. Accordingly, NPWT (gauzes or foams) that can be sealed by overlaying a sleeve simplifies the process, lowers the number of manipulations and thus speeds up the execution time.

     

    Conclusion

    This type of dressing is therefore particularly interesting for extremities (including hand and foot) in a setting where repeated dressing changes are needed.

    Further versions
  9. Poster

    When you have End Stage Heart Failure, 85, your legs leak and you’ve had previous ulcers…. Help!‘

    Poster presented at Wounds UK 2019 04.11.2019 Harrogate, UK
  10. Poster

    Can monofilament fibre technology help in chronic wound overgranulation? A case study

    Poster presented at Wounds UK 2019 04.11.2019 Harrogate, UK