Unsere Forschungs- und Entwicklungsteams sind weltweit im Einsatz und generieren Synergien aus unserem Expertenwissen und verwandten Fachdisziplinen. Wir stehen im internationalen Austausch mit unabhängigen Fachinstitutionen, Key Opinion Leadern und Multiplikatoren, um so Kooperations- und Wissensmanagement auf höchstem Niveau gewährleisten zu können. Im Rahmen dessen führen wir umfangreiche Forschungen durch, die kontinuierlich auf Kongressen in Form von Postern oder freien Vorträgen unserer Kooperationspartner sowie in Symposien und Workshops präsentiert und in namhaften wissenschaftlichen Fachzeitschriften veröffentlicht werden. Die größtenteils von unabhängigen Gutachtern bewerteten, evidenzbasierten Fachpublikationen, stellen wir Ihnen in dieser Datenbank zur Verfügung:
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Poster
Evaluation clinique d’un pansement à base de cellulose et de polyhexanide
Poster presented at CPC 2009 18.01.2009 Paris, FranceProducts Suprasorb X, Suprasorb X + PHMB -
Poster
Prise en charge d’une escarre récalcitrante par un pansement HydroBalance*
Poster presented at CPC 2009 18.01.2009 Paris, FranceProducts Suprasorb X -
Poster
L'évaluation des antiseptiques utilisés pour les plaies dans les conditions de tests de provocation de résistance avec des souches internationales de SARM
Poster presented at CPC 2009 18.01.2009 Paris, FranceProducts Suprasorb X + PHMB -
Journal article
VIABILITY AND PROLIFERATION OF FIBROBLASTS, KERATINOCYTES AND HACAT-CELLS INFLUENCED BY POLLHEXANTDE
Wound Rep Reg 2009 17 83Downloads Citation (RIS)Further versionsFurther languages -
Journal article
Development and Implementation of a Clinical Pathway To Improve Venous Leg Ulcer Treatment
Wounds 2009 21(5) 127133Downloads Citation (RIS) -
Journal article
INTÉRET DU PANSEMENT HYDROBALANCE DANS LES PLAIES AIGUES ET CHRONIQUES · EXPÉRIENCE DU SUPRASORB®X
JOURNAL DES PLAIES ET CICATRISATIONS 2009 68(8) 5658Products Suprasorb XDownloads Citation (RIS) -
Journal article
PROTECTJVE EFFECT OF POLIHEXANIDE ON HACAT KERATINOCYTES IN CO-CULTURE WITH STAPHYLOCOCCUS AUREUS
Wound Rep Reg 2009 17 84Products Suprasorb X + PHMBDownloads Citation (RIS) -
Journal article
New HydroBalance concept tested in the primary health care sector
EWMA Journal 2009 9(2)Products Suprasorb X, Suprasorb X + PHMBDownloads Citation (RIS) -
Journal article
Monitoring the microcirculation to evaluate dressing performance in patients with venous leg ulcers
Journal of wound care 2009 18(4) 145150OBJECTIVE
To compare the effect on the microcirculation in venous leg ulcers (VLUs) of two treatment regimens that promote a moist wound environment versus paraffin gauze. The hypothesis is that moist wound dressings are more likely to stimulate the microcirculation and therefore angiogenesis.
METHOD
Patients with non-healing VLUs were randomised to receive either a foam dressing (Suprasorb P), a collagen dressing (Suprasorb C) plus the foam dressing, or paraffin gauze (control). All patients wore short-stretch high compression bandages. Parameters used to measure the effects of the treatments on the microcirculation were: TcPO2 measurements, video laser Doppler measurements and the number of capillaries in the wound bed. The progression towards healing was measured by the reduction in ulcer area and formation of granulation tissue. The treatment period was four weeks.
RESULTS
Significant increases in TcPO2 values were reported between baseline and week 4 for patients receiving the foam dressing only or the collagen plus foam dressing combination (p<0.008 versus p<0.003 respectively). There was also a significant increase in the number of capillaries for the collagen plus foam treatment only (p<0.002).
CONCLUSION
This pilot study suggests that a moist wound environment stimulates perfusion of blood and oxygen to the wound tissue, thereby promoting angiogenesis. The collagen and foam dressing combination demonstrated superior results to the control and the foam dressing only. Monitoring the microcirculation may help to assess the effect of dressings on VLU healing, although more research is needed.
DECLARATION OF INTEREST
This pilot study was supported by a limited grant from Lohmann & Rauscher GmbH, Germany.
Products Suprasorb C, Suprasorb PPMID 19349934Downloads Citation (RIS) -
Journal article
Effect of the sterilization method on the performance of collagen type I on chronic wound parameters in vitro
Journal of biomedical materials research. Part B, Applied biomaterials 2009 90(2) 710719In the treatment of chronic wounds, it is necessary to establish a physiological wound milieu to improve healing. Application of collagen as wound dressing has been described as beneficial as it possesses the ability to reduce elevated levels of proteases, cytokines, and free radicals. Consequently, a wide range of wound dressings based on collagen have been developed. Native collagen is susceptible to alterations because of influences during the production process; to minimize effects on the molecule itself collagen wound dressings are usually aseptically produced. Common sterilization methods (autoclaving, irradiation, and ethylene oxide (EtO) treatment) can induce changes in the protein chemistry and physical properties, potentially affecting the absorption rate, mechanical strength, or performance. In this study, we have evaluated the influence of gamma- and beta-irradiation as well as EtO sterilization on the binding capacity of collagen type I for selected proteases and cytokines associated with nonhealing wounds. Although a pronounced effect on the physical properties of the collagen was found, there was no significant loss in the binding affinity for polymorphonuclear elastase, matrix metalloproteinase-2, and interleukin-1beta, or in the antioxidant capacity.
Products Suprasorb CPMID 19213054Downloads Citation (RIS)