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    Our research and development teams operate at a global level and generate synergies from our collective expertise and by drawing on related disciplines. We are also constantly exchanging information at an international level with independent technical institutions, key opinion leaders and multipliers in order to be able to ensure cooperation and knowledge management of the highest order. As part of this process, we also conduct extensive research, the results of which we continually present in workshops, at conferences and symposiums - either in documentation or talks given by our cooperation partners - and also publish in renowned scientific journals. This database contains a large number of these evidence-based scientific articles, most of which have been evaluated by independent assessors:

    1. Journal article

      THE EFFECT OF SUPRASORß X 0N HARD TO HEAL ULCERS. A NON CONTROLLED PROSPECTIVE ANALYSIS ON 96 PATIENTS

    2. Journal article

      THE AUTOLYTIC DEBRIDEMENT OF VENOUS LEG ULCERS

      Wound Essentials 2007 2 6873

      Wound debridement is part of the wound healing process which may occur without intervention but, more often, assistance is needed. It is important to recognise the situations when debridement is not appropriate. This article will describe how to recognise dead tissue that should be removed from the wound, when debridement should not be attempted and the various methods that canbe used.

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    3. Journal article

      Die suffiziente Kompression bei ambulanten Patienten mit venösen Ulzera: Möglichkeiten, Chancen und Grenzen der Pflege

      Journal of Wound Healing 2007 121122
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    4. Journal article

      Hydrobalance e medicazioni avanzate: un nuovo approccio nella gestione del processo di wound healing

      ACTA VULNOLOGICA 2007 5(3) 22

      Le moderne tecnologie hanno messo a disposizione medicazioni avanzate "Hydrobalance" in grado di gestire il diverso grado di urnidita di lesioni croniche unhealing, idratando o assorbendo l'essudato in eccesso dal wound bed.

       

      Obiettivo

      Obiettivo dello studio e valutare l'efficacia di un prodotto a base di biocellulosa umida "Suprasorb X" nel realizzare e mantenere un rnicroambiente con un livello di umidita corretto (HydroBalance), in grado di riattivare il processo di guarigione e favorire Ia riepitelizzazione di ulcere unhealing. Materiali e metodi - Sono stati arruolati nel presente studio 10 pazienti di eta compresa tra i 50 anni e gli 80 anni, affetti da ulcere ad eziologia diversa (venose, arteriose, diabetiche, vasculitiche, miste) di dimensioni comprese tra 5 e 10 cm, con e senza infezione, trattati rispettivamente con Suprasorb X e Suprasorb X+ PHMB. 11 protocollo di trattamento prevede ehe i pazienti vengano sottoposti a medicazione ogni 72 ore nel seguente modo: detersione con soluzione fisiologica, applicazione di Suprasorb X come medicazione prirnaria e di Suprasorb P schiuma di poliuretano come medicazione secondaria. Per valutare l'efficacia di "Suprasorb X" e stato adottato un metodo "digitale computerizzato" ehe permette attraverso l'elaborazione di una foto digitale di calcolare Ia superficie dell'ulcera e l'indice di riepitelizzazione giornaliero espresso in mm2/ die.

       

      Risultati

      I risultati ottenuti hanno messo in evidenza ehe i pazienti trattati con "Suprasorb X" e con "Suprasorb X"+ PHMB hanno mostrato un indice medio di riepitelizzazione di 20 mm2/ die. Questo risultato puo essere considerato estremamente valido se correlato all'indice di riepitelizzazione medio di ulcere vasculitiche, diabetiche, ischerniche il cui valore risulta essere estremamente basso 1-2 mm2/ die.

       

      Conclusioni

      In conclusione il prodotto oltre a risultare sicuramente efficace e versatile nel favorire il processo di guarigione di lesioni ulcerative difficili ad etiologia diversa, riduce significativamente Ia sintomatologia dolorosa, questo dato puo essere correlato alla capacita di Suprasorb X di gestire le variazioni di umidita ehe continuamente si verificano a livello del wound bed, e sara argomento di un successivo studio.

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    5. Journal article

      Kombinierte Anwendung von Rosidal® mobil und Suprasorb® X bei Ulcus cruris venosum

      Vasomed 2007 19(1) 40
    6. Journal article

      Ulcera e linfedema

      ACTA VULNOLOGICA 2007 5(3) 20
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    7. Journal article

      Managing an extravasation wound in a premature infant

      Wounds UK 2007 3(1) 9091
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    8. Journal article

      Simultaneous changes of leg circumference and interface pressure under different compression bandages

      European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2007 33(4) 476482

      OBJECTIVES

      To assess the validity of measuring changes of sub bandage pressure and leg circumference in different body positions for an in vivo characterization of the elastic properties of bandage systems.

       

      DESIGN

      Experimental study.

       

      MATERIALS AND METHODS

      Different compression bandages were applied on the leg. The variations of interface pressure and leg circumference above the inner ankle (that depends on the elastic property of the bandage) were measured simultaneously by a pressure transducer and by strain-gauge plethysmography in 50 patients. Stiffness is defined as the increase of pressure per increase of circumference.

       

      RESULTS

      The most consistent parameter to differentiate elastic from inelastic bandages was the pressure-difference between the standing and the lying position corrected for the actual increase of leg circumference (modified static stiffness index, mSSI; sensitivity and specificity 100%). Neglecting the individual changes of the circumference and considering the pressure difference alone allows a differentiation which is slightly less accurate (sensitivity 100%, specificity 88%) but much simpler to use.

       

      CONCLUSIONS

      The static stiffness index is a useful tool to differentiate elastic from inelastic bandage material even without correction for the individual increase of leg circumference.

      Products Dauerbinde K
      PMID 17234436
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    9. Journal article

      In vitro binding of matrix metalloproteinase-2 (MMP-2), MMP-9, and bacterial collagenase on collagenous wound dressings

      Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007 15(4) 549555

      Chronic wounds are characterized by failure in wound-healing response and a delay in healing or nonclosure of the wounds. This results in a high effort in clinical treatment and/or home care. A major difference between acute wounds and chronic wounds is the imbalance of proteinase inhibitors and proteinase activity that regulates the degradation and regeneration of the extracellular matrix proteins. Collagen and collagen/oxidized regenerated cellulose dressings act as a competitive substrate for matrix metalloproteinase-2, matrix metalloproteinase-9, and bacterial collagenase and influence this imbalance positively. Both wound dressings, approved for chronic wound treatment, the bovine collagen type I sponge and the oxidized regenerated cellulose collagen sponge, did not differ significantly in their sorption profiles for all enzymes. In general, binding was enhanced with a longer incubation time. The density of the device and the accessible surface, which can be controlled by the manufacturing process, are the crucial factors for the efficiency of the wound dressing.

      Products Suprasorb C
      PMID 17650099
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    10. Journal article

      Fibroblasts, keratinocytes and HaCaT -cells proliferation influenced by polihexanide

      Experimental dermatology 2007 16 272
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