Vyhledávání publikace

Naše výzkumné a vývojové týmy pracují po celém světě a vytvářejí synergie z našich odborných znalostí a souvisejících odborných disciplín. Jsme v mezinárodním kontaktu s nezávislými odbornými institucemi, názorovými vůdci a multiplikátory, abychom tak mohli zajistit kooperativní a znalostní management na nejvyšší úrovni. V rámci toho provádíme rozsáhlé výzkumy, které jsou průběžně prezentovány na kongresech ve formě plakátů nebo přednášek našich spolupracujících partnerů a také na sympoziích a workshopech a publikovány v uznávaných odborných vědeckých časopisech. Odborné publikace, založené na důkazech a hodnocené většinou nezávislými znalci, jsou k dispozici v této databázi:

  1. Journal article

    Pre-emptive active drainage of reflux (PARD) in Ivor-Lewis oesophagectomy with negative pressure and simultaneous enteral nutrition using a double-lumen open-pore film drain (dOFD)

    Surgical endoscopy 2022

    BACKGROUND

    Postoperative reflux can compromise anastomotic healing after Ivor-Lewis oesophagectomy (ILE). We report on Pre-emptive Active Reflux Drainage (PARD) using a new double-lumen open-pore film drain (dOFD) with negative pressure to protect the anastomosis.

    METHODS

    To prepare a dOFD, the gastric channel of a triluminal tube (Freka®Trelumina, Fresenius) is coated with a double-layered open-pore film (Suprasorb®CNP drainage film, Lohmann & Rauscher) over 25 cm. The ventilation channel is blocked. The filmcoated segment is placed in the stomach and the intestinal feeding tube in the duodenum. Negative pressure is applied with an electronic vacuum pump (- 125 mmHg, continuous suction) to the gastric channel. Depending on the findings in the endoscopic control, PARD will either be continued or terminated.

    RESULTS

    PARD was used in 24 patients with ILE and started intraoperatively. Healing was observed in all the anastomoses. The median duration of PARD was 8 days (range 4-21). In 10 of 24 patients (40%) there were issues with anastomotic healing which we defined as "at-risk anastomosis". No additional endoscopic procedures or surgical revisions to the anastomoses were required.

    CONCLUSIONS

    PARD with dOFD contributes to the protection of anastomosis after ILE. Negative pressure applied to the dOFD (a nasogastric tube) enables enteral nutrition to be delivered simultaneously with permanent evacuation and decompression.

    PMID 34973079
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  2. Journal article

    Het verhaal van Amber: Complicaties na een Gastric bypass

    Nederlands Tijdschrift Voor Huidzorg 2022 12(2)

    Amber is 42 jaar en moeder van 3 prachtige kinderen. Van kleins af aan was ze al redelijk gezet en dat bleef zo ondanks veel pogingen om af te vallen. Haar vader is overleden vlak na haar geboorte, ook hij was veel te zwaar en had te hoge cholesterol waarden. Amber dacht: dit gaat mij niet gebeuren en ik ga hulp zoeken om af te vallen. Ze kwam in 2016 in het ziekenhuis in Almelo bij de internist terecht en kreeg daar allerlei onderzoeken inclusief een erfelijkheidsonderzoek in verband met haar vader. Tijdens de tweede afspraak bij de internist werd ze goed met haar neus op de feiten gedrukt. Amber: ‘Hij zei, er moet gauw iets gebeuren want anders wordt u geen 38 jaar oud. Hier schrok ik dus behoorlijk van. Mijn bloeddruk was te hoog, ik rookte, had diabetes en een super hoog cholesterol gehalte.’ Al snel kreeg Amber groen licht voor een gastric bypass. ‘Maar daarvoor moest ik wel een jaar lang een voorbereidend traject volgen’. De operatie vond uiteindelijk plaats in april 2017.

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  3. Journal article

    Endoscopic vacuum therapy in the upper gastrointestinal tract: When and how to use it

    Langenbeck's archives of surgery 2022

    BACKGROUND

    Endoscopic vacuum therapy (EVT) has emerged as a novel treatment option for upper gastrointestinal wall defects. The basic principle of action of EVT entails evacuation of secretions, removal of wound debris, and containment of the defect. Furthermore, there is increasing evidence that EVT reduces interstitial edema, increases oxygen saturation, and promotes tissue granulation and microcirculation. Various devices, such as macroporous polyurethane sponge systems or open-pore film drains, have been developed for specific indications. Depending on the individual situation, EVT devices can be placed in- or outside the intestinal lumen, as a stand-alone procedure, or in combination with surgical, radiological, and other endoscopic interventions.

    PURPOSE

    The aim of this narrative review is to describe the current spectrum of EVT in the upper gastrointestinal tract and to assess and summarize the related scientific literature.

    CONCLUSIONS

    There is growing evidence that the efficacy of EVT for upper GI leakages exceeds that of other interventional treatment modalities such as self-expanding metal stents, clips, or simple drainages. Owing to the promising results and the excellent risk profile, EVT has become the therapy of choice for perforations and anastomotic leakages of the upper gastrointestinal tract in many centers of expertise. In addition, recent clinical research suggests that preemptive use of EVT after high-risk upper gastrointestinal resections may play an important role in reducing postoperative morbidity.

    PMID 35041047
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  4. Poster

    Application of an antimicrobial cellulose wound dressing on infected lower leg ulcers: 2 case studies

    Poster presented at WoundsUK 2021 08.11.2021 Harrogate, UK

    Introduction:

    The treatment of infected chronic wounds is a challenge in everyday clinical practice. In the treatment of these wounds polyhexanide (PHMB) is the antiseptic of choice [1]. Patients with difficult personal backgrounds further complicate the successful treatment of these wounds. Two case studies of infected chronic lower leg ulcers are presented. The treatment was carried out with an antimicrobial wound dressing made of cellulose containing PHMB*.

     

    Method:

    Patient 1: A 27-year-old male patient from the UK with an infected venous leg ulcer on the right lower leg that had been present for 11 months (size: 315 cm², depth: 0.1 cm). Moderate exudation, odour and pain of VAS=7 present. A deep vein thrombosis has recently occurred. In addition, the patient suffers from drug addiction (intravenous), alcohol addiction and mental disorder. The patient was previously treated with a hydrogel-impregnated antimicrobial wound pad and a medical-grade honey dressing. The new treatment consisted of cleaning with a monofilament fibre debridement pad**, the antimicrobial cellulose dressing, a sterile absorbent compress and a tubular dressing as a secondary dressing.

     

    Patient 2: An 80-year-old male patient from Germany with a mixed gaiter ulcer on the right lower leg (size: 450 cm², depth: 1 cm). Before the patient was admitted for treatment, he had already had several inpatient hospital stays. Therapy with a split-thickness skin graft was unsuccessful. The wound is infected with multidrug resistant gram-negative bacteria (MDRGN bacteria). The patient has had several antibiosis. The patient showed a constant incompliance with regard to the therapy attempts. Finally, a healing attempt with medicinal clay took place on the advice of his alternative (non-medical) practitioner. The patient was taken over with a massive infection, severe exudation and odour formation. Wound and lower leg pain correspondent to 8 on the Visual Analogue Scale (VAS). The entire lower leg was oedematous and papular indurations were present in the area of the forefoot. The wound was covered with biofilm and partially with fibrin. The wound edges and the surrounding skin were inflamed. Individual lesions were present. The patient's hygiene was poor. The weekly treatment was as follows: The wound was first cleaned with a wound irrigation solution containing sodium hypochlorite and a monofilament fibre debridement pad. The primary wound dressing was the cellulose dressing with PHMB. A highly absorbent wound compress*** and a superabsorbent wound dressing‡ served as a secondary dressing. In addition, the edema was treated with a compression bandage‡‡.

     

    Results:

    Patient 1: After 14 days and 5 dressing changes, the wound pain had decreased significantly (VAS = 1). The wound odour was gone. While the beginning granulation of the previously stagnant wound was particularly positive from the point of view of the user, the patient was particularly pleased that the wound odour had disappeared and that wound exudate no longer penetrated the dressing. The treatment was continued accordingly.

     

    Patient 2: After 3 weeks, not only had the wound pain (VAS = 6-7) decreased, but the wound odour and signs of infection had disappeared. Granulation tissue was visible. After 4 weeks, the wound pain (VAS = 5-6) decreased even more. Although the patient acknowledged the success of the therapy and the reduction in pain, he stopped the treatment on the advice of his alternative practitioner.

     

    Discussion:

    Although the two cases involved patients with longstanding chronic wounds and difficult personal backgrounds, the users were able to heal the wound within a short time with the help of the antimicrobial cellulose wound dressing and adequate modern wound care. For the two users, the rapid treatment success, in the form of the beginning healing, was gratifying. For the patients, it was primarily the pain reduction and the decrease in wound odour that were particularly well received. This is not surprising, as these two factors play a major role in the patient's quality of life.

     

    Conclusion:

    The antimicrobial wound dressing proved to be a suitable for the treatment of infected chronic wounds.

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  5. Poster

    Multinational observational study on the performance, handling and safety of a new alginate wound dressing

    Poster presented at WoundsUK 2021 08.11.2021 Harrogate, UK

    Aim:

    Alginate dressings play an important role in modern wound care. Areas of application include exudate management, autolytic debridement and hemostasis. Users of the alginate dressings have high demands on performance, handling and safety. In order to meet these requirements, a new alginate wound dressing* was developed from a mixture of 80% alginate and 20% viscose. In the study presented, the wound dressing was tested for the properties described.

     

    Method:

    An observational study was carried out in clinical as well as outpatient settings at study centers in Germany, Austria and Poland. The users were asked to treat up to 8 patients with the new alginate according to the instructions for use. All patients were adults and suffered from highly exuding wounds which were either pressure injuries, arterial/venous ulcers, diabetic ulcers or postoperative wounds.

     

    Results / Discussion:

    The performance, measured in the parameters of time required for application and adaptation to the wound bed in dry and gelled conditions, was rated on average by users as good or very good/excellent on a 6-point Likert scale. More than 90% of the users stated that they could achieve their treatment goals, in particular exudate management, autolytic debridement and hemostasis. All handling parameters were also rated as good or very good on average. The alginate caused almost no maceration of the wound edge and was usually removed very easily in one piece.

     

    Conclusion:

    The alginate dressing met the performance, handling and safety requirements and was very positively received by users.

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  6. Poster

    Use of monofilament fibre debridement pad for hyperkeratosis in the community

    Poster presented at EWMA 2021 26.10.2021 Virtual Conference

    Aim:

    82 year old man with diabetes, congestive cardiac failure and mixed arterial vascular insufficiency had been treated in the home for diabetic health management and a chronic history of leg ulcers.

    Patient was suffering from hyperkeratosis and previous treatment was an elastic tubular bandage which was left on for 24 hours a day, 7 days a week.

    Method:

    A solution was required which would manage the hyperkeratosis, prevent further skin breakdown and prevent bacterial or fungal build up in the feet and legs. The solution had to be cost effective, gentle on skin and ensure quick, easy removal of excessive skin and debris.

    A monofilament fibre debridement pad* was used to clean, remove and descale the hyperkeratosis without damaging healthy skin.

    Results / Discussion:

    After initial treatment with monofilament fibre debridement pad, there was visible improvement and reduction in hyperkeratosis, no itch and reduction in odour.

    Once dead skin and hyperkeratosis was removed, patient was put on a structured skin care regime including cleansing, exfoliation and replenishing the skin barrier using emollients.

    Conclusion:

    Hyperkeratosis of the lower limb is a common skin condition that typically affects patients with chronic venous insufficiency. Patients are often embarrassed by the appearance of their skin, the hyperkeratotic scales and the unpleasant odour. The monofilament fibre debridement pad can be used by all healthcare professionals working in the community, and by patients. It’s effectiveness and ease of use may encourage patients or carers to take an active role in their care.

    Products Debrisoft Pad
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  7. Poster

    Evaluation of different schort-stretch compression systems with zinc for stasis dermatitis

    Poster presented at EWMA 2021 26.10.2021 Virtual Conference

    Aim: Stasis dermatitis is a common inflammatory dermatosis of the lower extremities. The mainstay is treatment of the underlying chronic venous insufficiency (CVI) with multimodal therapy, which is aimed at reducing oedema and venous hypertension. External compression with short stretch bandages, impregnated with zinc oxide, is used as first line therapy simultaneously reducing swelling and employing anti-inflammatory effects of zinc. Our aim was to compare two different short-stretch systems with zinc oxide, both from the patients and staff point of view.

    Method: 10 patients with bilateral stasis dermatitis were included in the study. 2 patients had only CVI, while 8 patients had phlebolymphoedema. Both legs were treated simultaneously. Self-adherent two-layer bandaging system with zinc1 was applied on one leg and zinc paste bandage2 and adhesive short-stretch system3 was applied on the other leg for 7 days. A questionnaire with was filled out by the patients and the staff. Overall skin inflammation improvement was also assessed.

    Results: Both systems proved to be easy and fast to apply. There were no differences in slippage or compliance during wear. Patients had no difficulties with mobility and wearing footwear while using either compression systems. 90% of patients reported that self-adherent bandaging system was at least as comfortable to wear as adhesive bandage. The skin condition was equally improved with both systems.

    Conclusion: Both self-adherent and adhesive short-stretch systems with zinc proved to be suitable treatment of stasis dermatitis in patients with venous insufficiency and phlebolymphoedema.

    Products Varicex
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  8. Poster

    Combining nursing and podiatry for successful outcomes in a community setting

    Poster presented at Wounds Australia National Conference 2021 04.05.2021 Virtual Conference, Australia

    Situation

    76 year old lady with systemic pneumococcal infection was in ICU for 6 weeks and now being treated in community nursing and podiatry care. 9 toes were affected with necrosis.

     

    Action(s) taken/ treatment provided

    Patient had black, hard necrotic toes which required debridement of tips, nail beds and removal of exposed dead bones. Toes are difficult to dress and required moisture for autolytic debridement. Patient also required a solution which will relieve pain.

    It was decided that a combined treatment of community nursing and podiatry would deliver the best outcome for this patient.

    • Podiatry: Sharp debridement, removal of nails and removal of protruding dead bony toe phalanges

    • Community nursing: Debridement with monofilament fibre pad (in combination with sharp debridement) and dressings for autolytic debridement and pain relief.

     

    Outcome(s)

    After 2 weeks of treatment on the left foot, black necrotic tissue has been softened to allow for further debridement. After 4 weeks of treatment, big toe almost healed and small amount of nail bed regrowth.

    After 2 weeks of treatment on the right foot, evidence of granulation and epithelialisation of toes and nail bed areas.

     

    Lesson(s) learned

    Working as a multi-disciplinary team alongside allied health is vital for the healing process and can help to achieve the best possible clinical and patient outcomes, particularly for complex wounds.

  9. Poster

    Treatment of post-surgical toe wound with monofilament fibre pad and second generation ionic hydrogel dressing

    Poster presented at Wounds Australia National Conference 2021 04.05.2021 Virtual Conference, Australia

    Situation

    44 year old man with chronic history of gout in many joints. The patient had surgical intervention on right big toe due to infection of joint, pain and bone osteomyelitis.

    At 2 week post-surgery, the patient experienced delayed healing, pain and odour from the wound. On presentation, the wound had heavy thick slough, undermining of edges and slight hypergranulation at base of wound.

     

    Action(s) taken/treatment(s) provided

    Monofilament fibre lolly was used to clean wound bed, disrupt and remove biofilm and slough. Second generation hydrogel dressing then applied to wound bed for autolytic debridement and softening of slough. Pain relief was instant and patient no longer required oral pain medication. Biocellulose hydrobalance dressing was also applied at day 4 to improve and speed up epithelialisation process.

     

    Outcome(s)

    Patient and clinician happy with progress in first 7 days. The treatment and dressings reduced pain and allowed the patient to walk and wear his own shoes. Wound was fully healed after 26 days.

     

    Lesson(s) learned

    The use of monofilament fibre lolly combined with additional autolytic debridement with second generation ionic hydrogel dressing helped to prepare the wound bed and removed slough, debris and other barriers to healing. Further treatment with hydrogel dressing and hydrobalance dressing helped to create optimal conditions for wound healing.

  10. Poster

    First experience with new second generation ionic gel dressing: A spider bite gone wrong

    Poster presented at Wounds Australia National Conference 2021 04.05.2021 Virtual Conference, Australia

    Situation

    Patient presented to Hospital in the Home with large wound on the right leg which was suspected to have been caused by a spider bite. The patient was suffering from extreme pain, swelling and blistering.

     

    Action(s) taken/ treatment provided

    Wound needed debridement in the clinic to remove necrotic tissue and hardened slough. Due to the wound size and complexity, a combination of debridement methods were chosen, including mechanical with monofilament fibre pad, sharp and autolytic with ionic gel dressing. After full debridement was achieved, the wound bed was able to be thoroughly assessed and wound care plan put in place. Dressing regime included ongoing use of monofilament fibre pad for mechanical debridement and wound bed preparation and gel dressing for pain relief and dynamic fluid management.

     

    Outcome(s)

    The dressings were well tolerated and comfortable for the patient. Over the 4 months of treatment, the wound progressed towards healing and no surgical/specialist intervention or lengthy hospital stay was required.

     

    Lesson(s) learned

    Wounds with this level of complexity are often not expected to be treated in community settings. With introduction of new products onto the hospital formulary due to a new contract, new technologies were able to be used by the community nurse with successful patient outcomes. The products selected were cost effective, easy to use and reduced the need for antimicrobial dressings. Moving forward, products such as the new second generation ionic gel dressing can be used effectively in the community, reducing the need for specialist intervention.